당신이 사는 곳 – 당신을 더 빨리 늙게 할 수 있는 놀라운 요인

McMaster University의 연구원들이 주도한 최근 연구에 따르면, 경제적으로나 사회적으로 열악한 도시 지역에 살면서 우울함을 느끼면 노화 과정을 가속화할 수 있습니다.

6월 5일에 발표된 연구 노인학 저널, 시리즈 A: 생물학 및 의학, 사회적 자원과 기회의 큰 격차를 특징으로 하는 도시 지역에 거주하는 것과 우울 증상의 시작이 독립적으로 조기 생물학적 노화와 연관되어 있음을 보여주었습니다. 이 연관성은 만성 질환 및 유해한 건강 습관과 같은 개인 건강 및 행동 위험 요소를 고려한 후에도 지속됩니다.

McMaster University의 건강 연구 방법, 증거 및 영향학과 교수인 Parminder Raina는 네덜란드, 노르웨이 및 스위스의 조사자를 포함하는 연구팀을 이끌었습니다.

파민더 레이나(Parminder Raina), 맥마스터 대학(McMaster University)의 건강 연구 방법, 증거 및 영향학과 교수, 캐나다 노화 종단 연구(Canadian Longitudinal Study of Aging)의 수석 연구원이자 이 연구의 수석 저자. 크레딧: 맥마스터 대학교

우리 연구는 두 가지를 사용했습니다.[{” attribute=””>DNA methylation-based estimators, known as epigenetic clocks, to examine aging at the cellular level and estimate the difference between chronological age and biological age,” said Divya Joshi, the study’s first author and a research associate in the Department of Health Research Methods, Evidence, and Impact at McMaster.

“Our findings showed that neighborhood deprivation and depressive symptoms were positively associated with acceleration of the epigenetic age estimated using the DNAm GrimAge clock. This adds to the growing body of evidence that living in urban areas with higher levels of neighborhood deprivation and having depression symptoms are both associated with premature biological aging.”

Depressive symptoms in the study were measured using a 10-item standardized depression scale. The researchers found an acceleration in the risk of death by one month for every point increase in the depressive symptom score. They theorized that emotional distress caused by depression may result in more biological wear and tear and dysregulation of physiological systems, which in turn could lead to premature aging.

The researchers assessed neighborhood material and social deprivation using two indices that were developed by the Canadian Urban Environmental Health Research Consortium (CANUE) based on 2011 census.

Social deprivation reflects the presence of fewer social resources in the family and community, and material deprivation is an indicator of people’s inability to access goods and conveniences of modern life, such as adequate housing, nutritious food, a car, high-speed internet, or a neighborhood with recreational facilities.

The researchers found an increase in the risk of death by almost one year for those exposed to greater neighborhood deprivation compared to lower neighborhood deprivation.

The study did not find that neighborhood deprivation amplified the effect of depressive symptoms on epigenetic age acceleration.

“Our results showed that the effect of neighborhood deprivation on epigenetic age acceleration was similar regardless of depression symptoms, suggesting that depression influences epigenetic age acceleration through mechanisms unrelated to neighborhood deprivation,” Joshi said.

The research examined epigenetic data from 1,445 participants enrolled in the Canadian Longitudinal Study on Aging (CLSA), a research platform following more than 50,000 participants who were between the ages of 45 to 85 when recruited.

“Longitudinal studies, like the CLSA, are important to confirm associations like those found in this study,” said Raina, the study’s senior author and lead principal investigator of the CLSA.

“By following the same group of participants for 20 years, we will be able to determine whether epigenetic changes are stable or reversible over time. We will also gain insight into the mechanisms that are leading to accelerated epigenetic aging.”

Reference: “Association of Neighborhood Deprivation and Depressive Symptoms With Epigenetic Age Acceleration: Evidence From the Canadian Longitudinal Study on Aging” by Divya Joshi, Ph.D., Frank J van Lenthe, Ph.D., Martijn Huisman, Ph.D., Erik R Sund, Ph.D., Steinar Krokstad, Ph.D., Mauricio Avendano, Ph.D. and Parminder Raina, Ph.D., 5 June 2023, The Journals of Gerontology Series A.
DOI: 10.1093/gerona/glad118

Support for the CLSA is provided by the Government of Canada through the Canadian Institutes of Health Research and the Canada Foundation for Innovation. Additional support for this study was provided by the European Union Horizon 2020 Programme.